Phase out D4T in poor countries

In 2010 the World Health Organisation (WHO) changed the HIV treatment guidelines for poor countries and recommended switching from stavudine (D4T) to tenofovir disoproxil fumarate (TDF) for all patients on first line treatment. Stavudine (D4T) was previously one of three antiretroviral drugs (ARVs) recommended as first-line treatment but serious side effects, seen in many studies and treatment programmes, led to calls to use better, less toxic drugs.